|Application ||WB, E|
|Other Accession||NP_000261.2, 4860|
|Calculated MW||32118 Da|
|Other Names||Purine nucleoside phosphorylase, PNP, 220.127.116.11, Inosine phosphorylase, Inosine-guanosine phosphorylase, PNP, NP|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PNP (aa142-153) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm|
|Tissue Location||Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology|
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Provided below are standard protocols that you may find useful for product applications.
Metabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma. Vareed SK, et al. PLoS One. 2011 Mar 23;6(3):e17177. PMID: 21448452
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