|Application ||WB, E|
|Other Accession||NP_055981.1, 23209|
|Calculated MW||41141 Da|
|Other Names||Membrane protein MLC1, MLC1, KIAA0027, WKL1|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MLC1 (aa179-193) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasm, perinuclear region. Endoplasmic reticulum|
|Tissue Location||Expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_631941.1, NP_055981.1.
Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts. López-Hernández T, Sirisi S, Capdevila-Nortes X, Montolio M, Fernández-Dueñas V, Scheper GC, van der Knaap MS, Casquero P, Ciruela F, Ferrer I, Nunes V, Estévez R. Hum Mol Genet. 2011 Aug 15;20(16):3266-77. PMID: 21624973
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