|Other Accession||NP_443104.1, 112744|
|Calculated MW||18045 Da|
|Other Names||Interleukin-17F, IL-17F, Cytokine ML-1, IL17F|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL-17F (aa63-77) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).|
|Tissue Location||Expressed in activated, but not resting, CD4+ T-cells and activated monocytes|
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Interleukin 17A and F and asthma in Saudi Arabia: gene polymorphisms and protein levels. Bazzi MD, Sultan MA, Al Tassan N, Alanazi M, Al-Amri A, Al-Hajjaj MS, Al-Muhsen S, Alba-Concepcion K, Warsy A. J Investig Allergol Clin Immunol. 2011;21(7):551-5. PMID: 22312940
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