|Application ||WB, E|
|Other Accession||NP_054865.2, 7462|
|Calculated MW||26550 Da|
|Other Names||Linker for activation of T-cells family member 2, Linker for activation of B-cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 protein, Williams-Beuren syndrome chromosomal region 5 protein, LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LAT2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LAB, NTAL, WBS15, WBSCR15, WBSCR5|
|Function||Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts|
|Tissue Location||Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B- cells, NK cells and monocytes. Absent from T-cells (at protein level).|
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Reported variants represent identical protein: NP_115853.2, NP_115852.1, NP_054865.2
Homeostatic and innate immune responses: role of the transmembrane glycoprotein CD98. Nguyen HT, Merlin D.Nguyen HT, Merlin D.Nguyen HT, Merlin D.Nguyen HT, Merlin D. Cellular and molecular life sciences : CMLS 2012 Sep 69 (18): 3015-26. PMID: 22460579
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