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POLRMT Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | O00411 |
| Other Accession | NP_005026.3, 5442 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 138620 Da |
| Gene ID | 5442 |
|---|---|
| Other Names | DNA-directed RNA polymerase, mitochondrial, MtRPOL, 2.7.7.6, POLRMT |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | POLRMT Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | POLRMT (HGNC:9200) |
|---|---|
| Function | DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:21278163, PubMed:33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non- template strand (PubMed:29149603). Has DNA primase activity (PubMed:18685103, PubMed:33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed:18685103, PubMed:33602924). |
| Cellular Location | Mitochondrion |
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Provided below are standard protocols that you may find useful for product applications.
References
Structure of human mitochondrial RNA polymerase. Ringel R, Sologub M, Morozov YI, Litonin D, Cramer P, Temiakov D. Nature 2011 Oct 478 (7368): 269-73. PMID: 21947009
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