|Application ||WB, IHC, E|
|Other Accession||NP_001164185.1, NP_001164186.1, NP_001164187.1, NP_001164188.1, NP_001164189.1, NP_055382.2, NP_001164190.1, NP_001164191.1, NP_001164192.1, 9564, 12927 (mouse), 25414 (rat)|
|Predicted||Mouse, Rat, Dog|
|Calculated MW||93372 Da|
|Other Names||Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, BCAR1, CAS, CASS1, CRKAS|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCAR1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CAS, CASS1, CRKAS|
|Function||Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.|
|Cellular Location||Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.|
|Tissue Location||Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoforms1, 2, 3, 5, 6 and 7.
BCAR1 protein plays important roles in carcinogenesis and predicts poor prognosis in non-small-cell lung cancer. Huang W, Deng B, Wang RW, Tan QY, He Y, Jiang YG, Zhou JH. PloS one 2012 7 (4): e36124. PMID: 22558353
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