|Application ||WB, E|
|Other Accession||NP_000601.3, NP_001001389.1, NP_001001390.1, NP_001001391.1, NP_001001392.1, NP_001189484.1, NP_001189485.1, NP_001189486.1, 960|
|Calculated MW||81538 Da|
|Other Names||CD44 antigen, CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I, CD44, CD44, LHR, MDU2, MDU3, MIC4|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD44 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LHR, MDU2, MDU3, MIC4|
|Function||Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges.|
|Tissue Location||Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas Expression is repressed in neuroblastoma cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This antibody is expected to recognize reported isoforms 1, 2, 3, 4, 6, 7, 8 (NP_000601.3; NP_001001389.1; NP_001001390.1; NP_001001391.1; NP_001189484.1; NP_001189485.1; NP_001189486.1).
Moesin is a glioma progression marker that induces proliferation and Wnt/?-catenin pathway activation via interaction with CD44. Zhu X, Morales FC, Agarwal NK, Dogruluk T, Gagea M, Georgescu MM. Cancer research 2013 Feb 73 (3): 1142-55. PMID: 23221384
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