Transcription factor E2F1 (aa314-327) Antibody (internal region)
Peptide-affinity purified goat antibody
|Application ||WB, E|
|Other Accession||NP_005216.1, 1869|
|Calculated MW||46920 Da|
|Other Names||Transcription factor E2F1, E2F-1, PBR3, Retinoblastoma-associated protein 1, RBAP-1, Retinoblastoma-binding protein 3, RBBP-3, pRB-binding protein E2F-1, E2F1, RBBP3|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Precautions||Transcription factor E2F1 (aa314-327) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).|
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Provided below are standard protocols that you may find useful for product applications.
c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphomas. Hu F, Gartenhaus RB, Zhao XF, Fang HB, Minkove S, Poss DE, Rapoport AP. Leukemia research 2013 Apr 37 (4): 447-54. PMID: 23237560
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