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NELL2 Antibody (internal region, near C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q99435 |
| Other Accession | NP_001138579.1, NP_006150.1, NP_001138581.1, NP_001138582.1, 4753, 54003 (mouse), 81734 (rat) |
| Predicted | Human, Mouse, Rat, Pig, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 91346 Da |
| Gene ID | 4753 |
|---|---|
| Other Names | Protein kinase C-binding protein NELL2, NEL-like protein 2, Nel-related protein 2, NELL2, NRP2 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NELL2 Antibody (internal region, near C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NELL2 (HGNC:7751) |
|---|---|
| Synonyms | NRP2 |
| Function | Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (By similarity). Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline (PubMed:32198364). Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q62918}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize all reported isoforms (NP_001138579.1; NP_006150.1; NP_001138581.1; NP_001138582.1). Reported variants represent identical protein: NP_001138580.1, NP_006150.1.
References
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Kahle JJ, Gulbahce N, Shaw CA, Lim J, Hill DE, Barabási AL, Zoghbi HY. Hum Mol Genet. 2011 Feb 1;20(3):510-27. PMID: 21078624
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