|Application ||WB, E|
|Other Accession||NP_002988.3, 6382|
|Calculated MW||32462 Da|
|Other Names||Syndecan-1, SYND1, CD138, SDC1, SDC|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||syndecan 1 / CD138 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Secreted. Secreted, exosome. Note=Shedding of the ectodomain produces a soluble form.|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_001006947.1, NP_002988.3.
Removal of syndecan-1 promotes TRAIL-induced apoptosis in myeloma cells. Wu YH, Yang CY, Chien WL, Lin KI, Lai MZ. Journal of immunology (Baltimore, Md. : 1950) 2012 Mar 188 (6): 2914-21. PMID: 22308310
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