|Application ||WB, E|
|Other Accession||NP_000215.1, 3875, 16668 (mouse), 294853 (rat)|
|Predicted||Mouse, Rat, Pig, Dog, Cow|
|Calculated MW||48058 Da|
|Other Names||Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||keratin 18 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.|
|Cellular Location||Cytoplasm, perinuclear region. Nucleus, nucleolus|
|Tissue Location||Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.|
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Provided below are standard protocols that you may find useful for product applications.
Reported variants represent identical protein: NP_000215.1, NP_954657.1.
Keratin 18 attenuates estrogen receptor alpha-mediated signaling by sequestering LRP16 in cytoplasm. Meng Y, Wu Z, Yin X, Zhao Y, Chen M, Si Y, Yang J, Fu X, Han W. BMC cell biology 2009 10 : 96. PMID: 20035625
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