alpha-1-antichymotrypsin (aa222-236) Antibody (internal region)
Peptide-affinity purified goat antibody
|Application ||WB, E|
|Other Accession||NP_001076.2, 12|
|Calculated MW||47651 Da|
|Other Names||Alpha-1-antichymotrypsin, ACT, Cell growth-inhibiting gene 24/25 protein, Serpin A3, Alpha-1-antichymotrypsin His-Pro-less, SERPINA3, AACT|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||alpha-1-antichymotrypsin (aa222-236) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.|
|Tissue Location||Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains|
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Provided below are standard protocols that you may find useful for product applications.
Pivotal role for alpha1-antichymotrypsin in skin repair. Hoffmann DC, Textoris C, Oehme F, Klaassen T, Goppelt A, Römer A, Fugmann B, Davidson JM, Werner S, Krieg T, Eming SA. The Journal of biological chemistry 2011 Aug 286 (33): 28889-901. PMID: 21693707
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