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fibrinogen beta chain (aa177-190) Antibody (internal region)

Peptide-affinity purified goat antibody

  • WB - fibrinogen beta chain (aa177-190) Antibody (internal region) AF4079a
    AF4079a (0.01 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02675
Other Accession NP_005132.2, NP_001171670.1, 2244
Reactivity Human
Predicted Pig
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 55928 Da
Additional Information
Gene ID 2244
Other Names Fibrinogen beta chain, Fibrinopeptide B, Fibrinogen beta chain, FGB
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautionsfibrinogen beta chain (aa177-190) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGB
Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Cellular Location Secreted.
Research Areas
Citations (0)

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This antibody is expected to recognize both reported isoforms (NP_005132.2; NP_001171670.1).


Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor. Parastatidis I, Thomson L, Burke A, Chernysh I, Nagaswami C, Visser J, Stamer S, Liebler DC, Koliakos G, Heijnen HF, Fitzgerald GA, Weisel JW, Ischiropoulos H. The Journal of biological chemistry 2008 Dec 283 (49): 33846-53. PMID: 18818200

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$ 325.00
Cat# AF4079a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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