|Application ||WB, E|
|Other Accession||NP_109591.1, 1992|
|Calculated MW||42742 Da|
|Other Names||Leukocyte elastase inhibitor, LEI, Monocyte/neutrophil elastase inhibitor, EI, M/NEI, Peptidase inhibitor 2, PI-2, Serpin B1, SERPINB1, ELANH2, MNEI, PI2|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SERPINB1 (aa130-143) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ELANH2, MNEI, PI2|
|Function||Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.|
|Cellular Location||Cytoplasm. Cytoplasmic granule|
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SerpinB1 in cystic fibrosis airway fluids: quantity, molecular form and mechanism of elastase inhibition. Cooley J, Sontag MK, Accurso FJ, Remold-O'Donnell E. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011 May 37 (5): 1083-90. PMID: 20817705
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