|Application ||WB, E|
|Other Accession||NP_001279.2, 1192, 114584 (mouse), 406864 (rat)|
|Predicted||Mouse, Rat, Dog, Cow|
|Calculated MW||26923 Da|
|Other Names||Chloride intracellular channel protein 1, Chloride channel ABP, Nuclear chloride ion channel 27, NCC27, Regulatory nuclear chloride ion channel protein, hRNCC, CLIC1, G6, NCC27|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLIC1 / NCC27 (aa45-57) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.|
|Cellular Location||Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain|
|Tissue Location||Expression is prominent in heart, placenta, liver, kidney and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Transmembrane extension and oligomerization of the CLIC1 chloride intracellular channel protein upon membrane interaction. Goodchild SC, Angstmann CN, Breit SN, Curmi PM, Brown LJ. Biochemistry 2011 Dec 50 (50): 10887-97. PMID: 22082111
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