|Application ||WB, E|
|Other Accession||NP_005171.4, 648, 12151 (mouse)|
|Predicted||Mouse, Pig, Dog|
|Calculated MW||36949 Da|
|Other Names||Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1, PCGF4, RNF51|
|Format||0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BMI1 (aa237-251) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.|
|Cellular Location||Nucleus. Cytoplasm.|
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Provided below are standard protocols that you may find useful for product applications.
A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway. Cho JH, Dimri M, Dimri GP. The Journal of biological chemistry 2013 Feb 288 (5): 3406-18. PMID: 23239878
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