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Goat Anti-ILK (Restricted sale due to demands of patent holder) Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13418 |
| Other Accession | NP_004508.1, NP_001014794.1, NP_001014795.1, 3611 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 51419 Da |
| Gene ID | 3611 |
|---|---|
| Other Names | Integrin-linked protein kinase, 2.7.11.1, 59 kDa serine/threonine-protein kinase, ILK-1, ILK-2, p59ILK, ILK, ILK1, ILK2 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-ILK (Restricted sale due to demands of patent holder) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ILK (HGNC:6040) |
|---|---|
| Function | Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling (PubMed:10712922). Focal adhesion protein part of the complex ILK-PINCH (PubMed:10712922). This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway (PubMed:10712922). Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells (PubMed:10712922). Regulates cell motility by forming a complex with PARVB (PubMed:32528174). Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715). |
| Cellular Location | Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O55222}. Cytoplasm, myofibril, sarcomere |
| Tissue Location | Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
References
Hannigan G.E.,et al.Nature 379:91-96(1996).
Janji B.,et al.Oncogene 19:3069-3077(2000).
Tadic B.,et al.Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
Melchior C.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
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