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Goat Anti-IL17C (aa160-172) Antibody

Goat Anti-IL17C (aa160-172) Antibody (AF4142a)

     
  • WB - Goat Anti-IL17C (aa160-172) Antibody AF4142a
    AF4142a (0.3 µg/ml) staining of Human Lymph Node lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9P0M4
Other Accession NP_037410.1, 27189
Reactivity Human
Predicted Human
Concentration 100ug/200ul
Calculated MW 21765 Da
Additional Information
Gene ID 27189
Other Names Interleukin-17C, IL-17C, Cytokine CX2, IL17C
Immunogen Peptide with sequence RRPCSRDGSGLPT, from the internal region of the protein sequence according to NP_037410.1.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-IL17C (aa160-172) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL17C
Function Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Cellular Location Secreted.
Citations (0)

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Background

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

References

Li H.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:773-778(2000).
Zhang W.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Song X.,et al.Nat. Immunol. 12:1151-1158(2011).
Ramirez-Carrozzi V.,et al.Nat. Immunol. 12:1159-1166(2011).

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$ 335.00
Cat# AF4142a
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