|Application ||IHC, IF, E|
|Other Accession||NP_001700.2, NP_001700.2, NP_733928.1, NP_733929.1, NP_733930.1, NP_733931.1|
|Reactivity||Human, Mouse, Rat|
|Predicted||Human, Mouse, Rat, Dog|
|Calculated MW||27818 Da|
|Other Names||BDNF ; brain-derived neurotrophic factor; MGC34632; neurotrophin|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence ETKCNPMGYTKE, from the internal region of the protein sequence according to NP_001700.2; NP_001700.2; NP_733928.1; NP_733929.1; NP_733930.1; NP_733931.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-BDNF Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.|
|Tissue Location||Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta|
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Provided below are standard protocols that you may find useful for product applications.
BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Yoshii A, Constantine-Paton M. Nat Neurosci. 2007 Jun;10(6):702-711. Epub 2007 May 21.
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