|Application ||IHC, ICC, E|
|Other Accession||NP_000774.2, NP_476498.1|
|Calculated MW||56199 Da|
|Other Names||CYP26A1; cytochrome P450, family 26, subfamily A, polypeptide 1; CP26; CYP26; P450RAI; P450RAI1; P450, retinoic acid-inactivating, 1; cytochrome P450, subfamily XXVIA, polypeptide 1; retinoic acid 4-hydroxylase; retinoic acid-metabolizing cytochrome|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-NLPARFTHFHGE, from the internal region of the protein sequence according to NP_000774.2; NP_476498.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CYP26A1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
|Tissue Location||Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain|
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Murine toxicology and pharmacokinetics of novel retinoic acid metabolism blocking agents Patel JB, Khandelwal A, Chopra P, Handratta VD, Njar VC Cancer Chemother Pharmacol. 2007 Nov;60(6):899-905
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