Goat Anti-NFATC3 / NFAT4 Antibody (internal region (near N Terminus))
Purified Goat Polyclonal Antibody
|Application ||WB, E|
|Other Accession||NP_775188.1, NP_004546.1, NP_775186.1, NP_775187.1|
|Predicted||Human, Cow, Dog|
|Calculated MW||115594 Da|
|Other Names||NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; NFAT4; NFATX; T cell transcription factor NFAT4; nuclear factor of activated T-cells c3 isoform IE-Xa; nuclear factor of activated T-cells, cytoplasmic 3|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-HQELDAHEDDLQIN, from the internal region (near N Terminus) of the protein sequence according to NP_775188.1; NP_004546.1; NP_775186.1; NP_775187.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-NFATC3 / NFAT4 Antibody (internal region (near N Terminus)) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals The subcellular localization of NFATC plays a key role in the regulation of gene transcription|
|Tissue Location||Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle|
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A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells. Amasaki Y, Adachi S, Ishida Y, Iwata M, Arai N, Arai K, Miyatake S, J. Biol. Chem. 2002 Jul 277 (28): 25640-8.
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