|Application ||WB, E|
|Calculated MW||30748 Da|
|Other Names||IL1B; interleukin 1, beta; IL-1; IL1-BETA; IL1F2; IL-1 beta; catabolin; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-QLESVDPKNYPKK, from the internal region of the protein sequence according to NP_000567.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-IL-1 beta Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.|
|Cellular Location||Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins|
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Provided below are standard protocols that you may find useful for product applications.
NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infection. Cai S, Batra S, Wakamatsu N, Pacher P, Jeyaseelan S. Journal of immunology (Baltimore, Md. : 1950) 2012 Jun 188 (11): 5623-35.
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