|Other Accession||NP_937839.1, NP_005807.1|
|Calculated MW||65634 Da|
|Other Names||CD96; CD96 molecule; TACTILE; CD96 antigen; T cell activation, increased late expression; T-cell surface protein tactile; cell surface antigen CD96; t cell-activated increased late expression protein|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence KYTCIQEPNESD, from the C Terminus of the protein sequence according to NP_937839.1; NP_005807.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-CD96 Antibody (C Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells|
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CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Hosen N, Park CY, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M, Krensky AM, Weissman IL. Proceedings of the National Academy of Sciences of the United States of America 2007 Jun 104 (26): 11008-13.
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