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Goat Anti-Nanog Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q80Z64 |
| Other Accession | 71950(mouse), NP_082292.1 |
| Reactivity | Mouse |
| Predicted | Mouse |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 34240 Da |
| Gene ID | 71950 |
|---|---|
| Other Names | Nanog; Nanog homeobox; 2410002E02Rik, ENK, ecat4; ES cell-associated protein 4; early embryo specific expression NK family; early embryo specific expression NK-type homeobox protein; homeobox protein NANOG; homeobox transcription factor Nanog |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-DLEVNLEATRESHAH, from the internal region of the protein sequence according to NP_082292.1 . |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-Nanog Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Nanog |
|---|---|
| Synonyms | Ecat4, Enk |
| Function | Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal (PubMed:25825768). Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'- TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (By similarity). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15582778} |
| Tissue Location | Not expressed in oocytes and spermatogonia (at protein level). Not expressed in many somatic organs, ovary, testis, fibroblast and hematopoietic cell lines. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Nanog reverses the effects of organismal aging on mesenchymal stem cell proliferation and myogenic differentiation potential. Han J, Mistriotis P, Lei P, Wang D, Liu S, Andreadis ST. Stem cells (Dayton, Ohio) 2012 Dec 30 (12): 2746-59.
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$ 341.00
Cat# AF4184a
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