|Application ||WB, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||26152 Da|
|Other Names||LGALS3; lectin, galactoside-binding, soluble, 3 ; CBP35; GAL3; GALBP; GALIG; LGALS2; MAC2 ; IgE-binding protein; MAC-2 antigen; carbohydrate-binding protein 35; galactose-specific lectin 3; galectin 3; galectin-3 internal gene; laminin-binding protein; lectin, galactoside-binding, soluble, 3 (galectin 3)|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence CNTKLDNNWGREERQ, from the internal region of the protein sequence according to NP_002297.2.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Galectin 3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.|
|Cellular Location||Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface|
|Tissue Location||A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages Expressed in fetal membranes.|
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Increased galectin-3 expression and intraepithelial neutrophils in small airways in severe chronic obstructive pulmonary disease. Pilette C, Colinet B, Kiss R, Andre S, Kaltner H, Gabius HJ, Delos M, Vaerman JP, Decramer M, Sibille Y. Eur Respir J. 2007 Jan 24; [Epub ahead of print]
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