|Application ||WB, E|
|Calculated MW||62542 Da|
|Other Names||SLC40A1; solute carrier family 40 (iron-regulated transporter), member 1; FPN1; HFE4; IREG1; MST079; MTP1; SLC11A3; iron regulated gene 1; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3; solute carrier family 40 member 1|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-ELKQLNLHKDTEPKP, from the internal region of the protein sequence according to NP_055400.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-SLC40A1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FPN1, IREG1, SLC11A3|
|Function||May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Localized to the basolateral membrane of polarized epithelial cells|
|Tissue Location||Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen|
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Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination. Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E. Cell metabolism 2012 Jun 15 (6): 918-24.
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