|Application ||WB, E|
|Other Accession||106759(mouse), 363328(rat), NP_891549.1|
|Predicted||Human, Mouse, Rat, Pig, Cow, Dog|
|Calculated MW||76422 Da|
|Other Names||TICAM1; toll-like receptor adaptor molecule 1; PRVTIRB; TICAM-1; TRIF; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; proline-rich, vinculin and TIR domain-containing protein B; putative NF-kappa-B-activating protein 502H; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence PDGATFCEDFQVP, from the internal region of the protein sequence according to NP_891549.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-TICAM-1 / TRIF Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.|
|Cellular Location||Cytoplasmic vesicle, autophagosome. Note=Colocalizes with UBQLN1 in the autophagosome.|
|Tissue Location||Ubiquitously expressed but with higher levels in liver.|
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Provided below are standard protocols that you may find useful for product applications.
Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist. Bowen WS, Minns LA, Johnson DA, Mitchell TC, Hutton MM, Evans JT. Science signaling 2012 Feb 5 (211): ra13.
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