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Goat Anti-TICAM-1 / TRIF Antibody (internal region)

Purified Goat Polyclonal Antibody

  • WB - Goat Anti-TICAM-1 / TRIF Antibody (internal region) AF4229a
    AF4229a (2 µg/ml) staining of Daudi lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IUC6
Other Accession 106759(mouse), 363328(rat), NP_891549.1
Reactivity Human
Predicted Human, Mouse, Rat, Pig, Cow, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5
Calculated MW 76422 Da
Additional Information
Gene ID 148022
Other Names TICAM1; toll-like receptor adaptor molecule 1; PRVTIRB; TICAM-1; TRIF; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; proline-rich, vinculin and TIR domain-containing protein B; putative NF-kappa-B-activating protein 502H; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence PDGATFCEDFQVP, from the internal region of the protein sequence according to NP_891549.1.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-TICAM-1 / TRIF Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein- interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
Tissue Location Ubiquitously expressed but with higher levels in liver.
Research Areas
Citations (0)

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Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist. Bowen WS, Minns LA, Johnson DA, Mitchell TC, Hutton MM, Evans JT. Science signaling 2012 Feb 5 (211): ra13.

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$ 325.00
Cat# AF4229a
(40 western blots)
Availability: 7-10 days
Bulk Size
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