|Application ||WB, E|
|Other Accession||21956(mouse), 24837(rat), NP_000355.2, NP_001001430.1, NP_001001431.1, NP_001001432.1|
|Reactivity||Human, Mouse, Pig|
|Predicted||Human, Mouse, Rat, Pig, Cow, Dog, Cat|
|Calculated MW||35924 Da|
|Other Names||TNNT2; troponin T type 2 (cardiac); CMH2; CMPD2; LVNC6; MGC3889; RCM3; TnTC; cTnT; OTTHUMP00000033864; OTTHUMP00000033865; OTTHUMP00000033866; OTTHUMP00000033867; OTTHUMP00000033870; OTTHUMP00000218095; cardiac muscle troponin T; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; troponin T, cardiac muscle; troponin T2, cardiac|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-TERKSGKRQTERE, from the internal region of the protein sequence according to NP_000355.2; NP_001001430.1; NP_001001431.1; NP_001001432.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-cardiac troponin T Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
|Tissue Location||Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart|
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin T. Zhang J, Zhang H, Ayaz-Guner S, Chen YC, Dong X, Xu Q, Ge Y Biochemistry. 2011 Jul 12;50(27):6081-92.
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