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> home > Products > Primary Antibodies > Signal Transduction > Goat Anti-GNA12 Antibody (internal region)
Goat Anti-GNA12 Antibody (internal region)
Purified Goat Polyclonal Antibody
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Application 
| WB, E |
|---|---|
| Primary Accession | Q03113 |
| Other Accession | 14673(mouse), 81663(rat), NP_031379.2, NP_001269369.1, NP_001269370.1, NP_001280021.1 |
| Reactivity | Human |
| Predicted | Human, Mouse, Rat, Pig, Cow, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 44279 Da |
| Gene ID | 2768 |
|---|---|
| Other Names | GNA12; guanine nucleotide binding protein (G protein) alpha 12; NNX3; RMP; gep; G-protein subunit alpha-12; WUGSC:H_GS165O14.2; g alpha-12; guanine nucleotide-binding protein subunit alpha-12 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-KKHFPDFRGDPHR, from the internal region of the protein sequence according to NP_031379.2; NP_001269369.1; NP_001269370.1; NP_001280021.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-GNA12 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNA12 |
|---|---|
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). |
| Cellular Location | Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q63210}. Lateral cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q63210}. Cytoplasm. Note=CDH1 enhances cell membrane localization. |
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia. Cox B, Sharma P, Evangelou AI, Whiteley K, Ignatchenko V, Ignatchenko A, Baczyk D, Czikk M, Kingdom J, Rossant J, Gramolini AO, Adamson SL, Kislinger T. Molecular & cellular proteomics : MCP 2011 Dec 10 (12): M111.012526.
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$ 341.00
Cat# AF4240a
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