|Application ||WB, E|
|Other Accession||14678(mouse), 81664(rat), NP_002061.1, NP_001159897.1|
|Predicted||Human, Mouse, Rat, Pig, Cow|
|Calculated MW||40451 Da|
|Other Names||GNAI2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1; GTP-binding regulatory protein Gi alpha-2 chain; adenylate cyclase-inhibiting G alpha protein; guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-2 subunit|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-PEYTGANKYDE, from the internal region of the protein sequence according to NP_002061.1; NP_001159897.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-GNAI2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Membrane; Lipid- anchor. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody|
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G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions. Kremer KN, Kumar A, Hedin KE. J Immunol. 2011 Sep 15;187(6):3177-85.
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