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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Goat Anti-ORL1 / LOX1 / LOXIN Antibody (N Terminus)   

Goat Anti-ORL1 / LOX1 / LOXIN Antibody (N Terminus)

Purified Goat Polyclonal Antibody

  • WB - Goat Anti-ORL1 / LOX1 / LOXIN Antibody (N Terminus) AF4254a
    AF4254a (0.1 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78380
Other Accession NP_002534.1, NP_001166103.1, NP_001166104.1
Reactivity Human
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 0.5
Calculated MW 30959 Da
Additional Information
Gene ID 4973
Other Names OLR1; oxidized low density lipoprotein (lectin-like) receptor 1; CLEC8A; LOX1; LOXIN; SCARE1; SLOX1; C-type lectin domain family 8 member A; OTTHUMP00000238950; OTTHUMP00000238954; OTTHUMP00000238955; OTTHUMP00000238958; hLOX-1; lectin-type oxidized LDL r
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence DLKIQTVKDQPDEK-C, from the N Terminus of the protein sequence according to NP_002534.1; NP_001166103.1; NP_001166104.1.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-ORL1 / LOX1 / LOXIN Antibody (N Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OLR1
Synonyms CLEC8A, LOX1
Function Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria.
Cellular Location Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation
Tissue Location Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.
Research Areas
Citations (0)

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Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells. Shi Y, Cosentino F, Camici GG, Akhmedov A, Vanhoutte PM, Tanner FC, Lüscher TF. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2090-7.

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$ 325.00
Cat# AF4254a
(40 western blots)
Availability: 7-10 days
Bulk Size
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