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Goat Anti-HDAC3 Antibody (internal region)

Purified Goat Polyclonal Antibody

  • WB - Goat Anti-HDAC3 Antibody (internal region) AF4260a
    AF4260a (0.1 µg/ml) staining of Jurkat nuclear lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15379
Other Accession 15183(mouse), 84578(rat), NP_003874.2
Reactivity Human
Predicted Human, Mouse, Rat, Pig, Cow, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5
Calculated MW 48848 Da
Additional Information
Gene ID 8841
Other Names HDAC3; histone deacetylase 3; HD3; RPD3; RPD3-2; SMAP45
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence C-NHAPSVQIHDVPAD , from the internal region of the protein sequence according to NP_003874.2.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-HDAC3 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC3
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Cellular Location Nucleus. Cytoplasm. Note=Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803).
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Histone deacetylase 3 participates in self-renewal of liver cancer stem cells through histone modification. Liu C, Liu L, Shan J, Shen J, Xu Y, Zhang Q, Yang Z, Wu L, Xia F, Bie P, Cui Y, Zhang X, Bian X, Qian C. Cancer letters 2013 Oct 339 (1): 60-9.

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$ 325.00
Cat# AF4260a
(40 western blots)
Availability: 7-10 days
Bulk Size
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