|Application ||WB, E|
|Other Accession||NP_002650.1, NP_001005376.1, NP_001005377.1|
|Calculated MW||36978 Da|
|Other Names||PLAUR; plasminogen activator, urokinase receptor; CD87; U-PAR; UPAR; URKR; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2; urokinase plasminogen activator surface receptor; urokinase-type plasminogen activator (uPA) receptor|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence C-RTGLKITSLTE , from the internal region of the protein sequence according to NP_002650.1; NP_001005376.1; NP_001005377.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-U-PAR / CD87 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.|
|Cellular Location||Cell membrane. Cell projection, invadopodium membrane. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner Isoform 2: Secreted.|
|Tissue Location||Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain|
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Provided below are standard protocols that you may find useful for product applications.
Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer. LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS. Cancer research 2013 Apr 73 (7): 2070-81.
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