|Application ||WB, E|
|Other Accession||50998(rat), NP_004636.1|
|Predicted||Human, Rat, Cow|
|Calculated MW||62608 Da|
|Other Names||COIL; coilin; CLN80; p80-coilin; coilin p80; p80|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence RLVRDNDCLRVKLE, from the internal region of the protein sequence according to NP_004636.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-Coilin Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.|
|Cellular Location||Nucleus. Nucleus, Cajal body|
|Tissue Location||Found in all the cell types examined.|
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Provided below are standard protocols that you may find useful for product applications.
Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines. Hearst SM, Gilder AS, Negi SS, Davis MD, George EM, Whittom AA, Toyota CG, Husedzinovic A, Gruss OJ, Hebert MD. J Cell Sci. 2009 Jun 1;122(Pt 11):1872-81.
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