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Anti-CBX3 / HP1 Gamma Antibody (Internal), Biotinylated

  • WB - Anti-CBX3 / HP1 Gamma Antibody (Internal), Biotinylated AF4280a
    Biotinylated antibody (0.3 µg/ml) staining of NIH3T3 lysate (35 µg protein in RIPA buffer), exactly mirroring its parental non-biotinylated product. Primary incubation was 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocker as a substitute for skimmed milk.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13185
Other Accession 11335, NP_009207.2, 12417, 297093
Reactivity Human, Mouse
Predicted Human, Mouse, Rat, Dog
Calculated MW 20811 Da
Additional Information
Gene ID 11335
Other Names gene regulation; chromobox; Transcriptional regulator
Target/Specificity No cross-reactivity expected with HP1-alpha and HP1-beta. Reported variants represent identical protein: NP_009207.2, NP_057671.2
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAnti-CBX3 / HP1 Gamma Antibody (Internal), Biotinylated is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX3
Function Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
Cellular Location Nucleus. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).
Research Areas
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$ 325.00
Cat# AF4280a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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