|Application ||WB, IHC, E|
|Other Accession||11335, NP_009207.2, 12417, 297093|
|Predicted||Human, Mouse, Rat, Dog|
|Calculated MW||20811 Da|
|Other Names||gene regulation; chromobox; Transcriptional regulator|
|Target/Specificity||No cross-reactivity expected with HP1-alpha and HP1-beta. Reported variants represent identical protein: NP_009207.2, NP_057671.2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Anti-CBX3 / HP1 Gamma Antibody (Internal), Biotinylated is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.|
|Cellular Location||Nucleus. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).|
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