|Application ||WB, E|
|Other Accession||NP_005162.1, 466|
|Calculated MW||29233 Da|
|Other Names||ATF1; activating transcription factor 1; EWS-ATF1; FUS/ATF-1; TREB36; cAMP-dependent transcription factor ATF-1; cyclic AMP-dependent transcription factor ATF-1|
|Format||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Immunogen||Peptide with sequence EDSHKSTTSETAPQ-C, from the N Terminus of the protein sequence according to NP_005162.1.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Goat Anti-ATF1 Antibody (N Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.|
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