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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CD34 Antibody [Clone ICO-115]   

CD34 Antibody [Clone ICO-115]

Purified Mouse Monoclonal Antibody

  •  - CD34 Antibody  [Clone ICO-115] AH10218
    Surface flow cytometric analysis of CD34 on KG-1 cells using CD34 Ab (ICO-115) (red) and isotype control Ab (green). PPI negative cell population was gated for analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P28906
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1, kappa
Clone Names ICO-115
Calculated MW 90-110kDa
Additional Information
Gene ID 947
Other Names Hematopoietic progenitor cell antigen CD34, CD34, CD34
Target/Specificity Blast cells of a chronic myeloid leukemia patient
Application Note Flow Cytometry 5ul (0.5ug) per test per one million cells.
Format 0.5 ml at 100ug/ml; Conjugated to AF647
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
PrecautionsCD34 Antibody [Clone ICO-115] is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD34
Function Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues
Research Areas
Citations (0)

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This antibody recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi’s sarcoma, but shows low specificity.


1. Felshow DM et al. Blood 97:3768-3775 (2001).
2. Sato T et al. Blood 94:2548-2554 (1999).

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$ 295.00
Cat# AH10218
(40 western blots)
Availability: 2-3 days
Bulk Size
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