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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CD63 (Late Endosomes Marker)Mouse Monoclonal Antibody [Clone MX-49.129.5]    

CD63 (Late Endosomes Marker)Mouse Monoclonal Antibody [Clone MX-49.129.5]

Purified Mouse Monoclonal Antibody

  •  - CD63 (Late Endosomes Marker)Mouse Monoclonal Antibody [Clone MX-49.129.5]  AH10368
    Flow Cytometric staining of mouse CD63 on NIH/3T3 Cells. Black: Cells alone; Green: Isotype Control; Red: PE-labeled CD63 MAb (MX-49.129.5).
  •  - CD63 (Late Endosomes Marker)Mouse Monoclonal Antibody [Clone MX-49.129.5]  AH10368
    Flow Cytometric staining of CD63 on human PBMC Cells. Black: Cells alone; Green: Isotype Control; Red: PE-labeled CD63 MAb (MX-49.129.5).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08962
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1, kappa
Clone Names MX-49.129.5
Calculated MW 26kDa (core protein); 30-60kDa (glycosylated)
Additional Information
Gene ID 967
Other Names gp55; granulophysin; Lysosomal-associated membrane protein 3 (LAMP-3); Mast cell antigen AD1; melanoma 1 antigen; Melanoma-associated antigen MLA1; Melanoma-associated antigen ME491; MLA1; NGA; Ocular melanoma-associated antigen; OMA81H; PTLGP40; Tetraspanin-30; TSPAN30
Target/Specificity Full length CD63 of human origin
Application Note Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood); Immunofluorescence (1:50-1:100); (Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.
Format 0.5ml at 100ug/ml with BSA and azide
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
PrecautionsCD63 (Late Endosomes Marker)Mouse Monoclonal Antibody [Clone MX-49.129.5] is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD63
Synonyms MLA1, TSPAN30
Function Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies
Tissue Location Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages
Research Areas
Citations (0)

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1.    C. Vennegoor et al., Int. J. Cancer 35: 287-295, 1985.
2.  AA Palmer et al., Pathology 17: 335-339, 1985.
3. EC Hagen et al., Histopathology 10: 689-700, 1986.

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$ 295.00
Cat# AH10368
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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