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CD90 / Thy1 (Anti-Mouse) (Stromal / Mesenchymal Marker) Antibody - With BSA and Azide
Rat Monoclonal Antibody [Clone IBL-6/23 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, FC |
|---|---|
| Primary Accession | P01831 |
| Other Accession | 21838 (Mouse), 3951 (Mouse) |
| Reactivity | Mouse |
| Host | Rat |
| Clonality | Monoclonal |
| Isotype | Rat / IgG1, kappa |
| Clone Names | IBL-6/23 |
| Calculated MW | 25kDa |
| Gene ID | 21838 |
|---|---|
| Other Names | Thy-1 membrane glycoprotein, Thy-1 antigen, CD90, Thy1, Thy-1 |
| Format | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD90 / Thy1 (Anti-Mouse) (Stromal / Mesenchymal Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Thy1 |
|---|---|
| Synonyms | Thy-1 |
| Function | May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Recognizes a protein of 25kDa, identified as mouse Thy-1 (also known as CD90). It is a glycosyl phosphatidylinositol-anchored surface glycoprotein. CD90 is a member of the immunoglobulin superfamily. It may contribute to inhibition of proliferation/differentiation of hematopoietic stem cells and neuron memory formation in the CNS. It consists of a single Ig domain (112 amino acids; 25-35kDa) inserted into the cell membrane via a GPI anchor. Thy-1 is expressed mainly on brain and lymphoid tissues including thymocytes, Peripheral T-cells, and some intraepithelial T-lymphocytes. Thy-1 may play a role in T cell activation, development and function of nervous system, and apoptosis.
References
Beissert S et al. Impaired cutaneous immune responses in Thy-1-deficient mice. J Immunol 1998, 161(10):5296-302Williams, A.F., and J. Gagnon. 1982. Neuronal cell Thy-1 glycoprotein: Homology with immunoglobulin. Science 216: 696 - 703Fujita N et al. Aggregation of Thy-1 glycoprotein induces thymocyte apoptosis through activation of CPP32-like proteases. Exp Cell Res 1997, 232(2):400-406 Kroczek, R.A., K.C. Gunter, R.N. Germain, and E.M. Shevach. 1986. Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes. Nature 322: 181 - 184
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