CD90 / Thy1 (Anti-Mouse) (Stromal / Mesenchymal Marker) Antibody - With BSA and Azide
Rat Monoclonal Antibody [Clone IBL-6/23 ]
|Application ||IF, FC|
|Other Accession||21838 (Mouse), 3951 (Mouse)|
|Isotype||Rat / IgG1, kappa|
|Other Names||Thy-1 membrane glycoprotein, Thy-1 antigen, CD90, Thy1, Thy-1|
|Format||200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CD90 / Thy1 (Anti-Mouse) (Stromal / Mesenchymal Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
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Recognizes a protein of 25kDa, identified as mouse Thy-1 (also known as CD90). It is a glycosyl phosphatidylinositol-anchored surface glycoprotein. CD90 is a member of the immunoglobulin superfamily. It may contribute to inhibition of proliferation/differentiation of hematopoietic stem cells and neuron memory formation in the CNS. It consists of a single Ig domain (112 amino acids; 25-35kDa) inserted into the cell membrane via a GPI anchor. Thy-1 is expressed mainly on brain and lymphoid tissues including thymocytes, Peripheral T-cells, and some intraepithelial T-lymphocytes. Thy-1 may play a role in T cell activation, development and function of nervous system, and apoptosis.
Beissert S et al. Impaired cutaneous immune responses in Thy-1-deficient mice. J Immunol 1998, 161(10):5296-302Williams, A.F., and J. Gagnon. 1982. Neuronal cell Thy-1 glycoprotein: Homology with immunoglobulin. Science 216: 696 - 703Fujita N et al. Aggregation of Thy-1 glycoprotein induces thymocyte apoptosis through activation of CPP32-like proteases. Exp Cell Res 1997, 232(2):400-406 Kroczek, R.A., K.C. Gunter, R.N. Germain, and E.M. Shevach. 1986. Thy-1 functions as a signal transduction molecule in T lymphocytes and transfected B lymphocytes. Nature 322: 181 - 184
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