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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >    HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - With BSA and Azide   

HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone HCGb/211 ]

     
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Primary Accession P01233
Other Accession 1082, 172944
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1
Clone Names HCGb/211
Calculated MW 22kDa
Additional Information
Other Names Choriogonadotropin subunit beta, CG-beta, Chorionic gonadotrophin chain beta, CGB, CGB3
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions HCG-beta (Pregnancy & Choriocarcinoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Research Areas
Citations (0)

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Background

This MAb reacts with a protein of 22kDa, identified as β sub-unit of HCG. It does not cross react with the α sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the ? and ? subunits. The ? subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.

References

Cocquebert M et. al. Am J Physiol Endocrinol Metab. 2012;303(8):E950-8

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Cat# AH11069
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