AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone AMPD3/901 ]
|Application ||IHC-F, IF, FC, ICC|
|Other Accession||272, 501890|
|Isotype||Mouse / IgG2b, kappa|
|Other Names||AMP deaminase 3, 188.8.131.52, AMP deaminase isoform E, Erythrocyte AMP deaminase, AMPD3|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||AMP deaminase plays a critical role in energy metabolism.|
|Tissue Location||Isoform 1 is the predominant form in skeletal muscle; Isoform 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; Isoform 3 is found in erythrocytes|
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Provided below are standard protocols that you may find useful for product applications.
It recognizes a protein of ~90kDa, which is identified as Adenosine Monophosphate Deaminase, isoform E (AMPD3). It has 767 amino acids and is assigned an EC 184.108.40.206. It is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. AMPD3 gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. This MAb shows reactivity with cells of the erythroid lineage at all stages of maturation in the peripheral blood, bone marrow, and fetal liver. Non-erythroid lineages are negative by flow cytometry. This MAb is useful in the diagnosis of erythroleukemia, identification of bone marrow erythroid precursors, gating erythroid nucleated precursor cells from malignant cells in bone marrow specimens.
Sabina RL, Waldenstrm A, Ronquist G. The contribution of Ca+ calmodulin activation of human erythrocyte AMP deaminase (isoform E) to the erythrocyte metabolic dysregulation of familial phosphofructokinase deficiency. Haematologica. 2006;91(5):652-5
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