Prostate Specific Antigen (PSA) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone KLK3/801 ]
|Application ||IHC, IF, FC|
|Other Accession||354, 171995|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Prostate-specific antigen, PSA, 18.104.22.168, Gamma-seminoprotein, Seminin, Kallikrein-3, P-30 antigen, Semenogelase, KLK3, APS|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Prostate Specific Antigen (PSA) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.|
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Provided below are standard protocols that you may find useful for product applications.
Recognizes a single protein of 33-34kDa, identified as the prostate specific antigen (PSA). This MAb is highly specific to PSA and stains prostatic secretory and ductal epithelium in both normal and neoplastic tissues. PSA is a chymotrypsin-like serine protease (kallikrein family) exclusively produced by the prostate epithelium, and abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign prostate hyperplasia.
Watt, K.W., et al. 1986. Human prostate-specific antigen: structural and functional similarity with serine proteases. Proc. Natl. Acad. Sci. USA 83: 3166-3170. |
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