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Neurofilament (NF-L) (Neuronal Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone NFL/736 ]

     
  • IHC -  Neurofilament (NF-L) (Neuronal Marker) Antibody - With BSA and Azide AH12003-20
    Formalin-fixed, paraffin-embedded Rat Cerebellum stained with Neurofilament Monoclonal Antibody (NFL/736).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, IF, FC
Primary Accession P07196
Other Accession 4747, 521461
Reactivity Human, Rat, Pig, Chicken, Cow
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1
Clone Names NFL/736
Calculated MW 68kDa
Additional Information
Gene ID 4747
Other Names Neurofilament light polypeptide, NF-L, 68 kDa neurofilament protein, Neurofilament triplet L protein, NEFL, NF68, NFL
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Neurofilament (NF-L) (Neuronal Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEFL
Synonyms NF68, NFL
Function Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
Research Areas
Citations (0)

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Background

This MAb reacts with a 68kDa protein, identified as light sub-unit of neurofilaments (NF-L). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68kDa (NF-L), 160kDa (NF-M) and 200kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.

References

Angelides, K.J., et. al. 1989. J. Cell Biol. 108: 1495-1506. |

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Cat# AH12003-20
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