|Application ||IHC, IF, FC|
|Other Accession||6480, 207459|
|Isotype||Mouse / IgM, kappa|
|Other Names||Beta-galactoside alpha-2, 6-sialyltransferase 1, Alpha 2, 6-ST 1, 22.214.171.124, B-cell antigen CD75, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 1, ST6Gal I, ST6GalI, Sialyltransferase 1, ST6GAL1, SIAT1|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||CDw75 (B-Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transfers sialic acid from CMP-sialic acid to galactose- containing acceptor substrates.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid|
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Recognizes a neuraminidase-sensitive sialoprotein (CDw75), present on cell membrane and cytoplasm of germinal center B-cells and derived lymphomas. This MAb reacts with RBC precursors of bone marrow, ductal and ciliated epithelial cells of kidney, breast, prostate, pancreas, lung, and with glioblastomas, astrocytomas, and Reed Sternberg cells in lymphocyte predominant Hodgkin s disease. It is shown to be a helpful antibody for ascribing a B-cell phenotype in known lymphoid tissues.
Epstein AL et. al. J of Immunology 133: 1028-1036, 1984. | Marder RJ et. al. Lab Invest 52: 497-504, 1985. |
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