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CD43 (T-Cell Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone SPN/1094 ]

  • IHC -  CD43 (T-Cell Marker) Antibody - With BSA and Azide AH12363
    Formalin-fixed, paraffin-embedded human Lymphoma stained with CD43 Monoclonal Antibody (SPN/1094).
  • IHC -  CD43 (T-Cell Marker) Antibody - With BSA and Azide AH12363
    Formalin-fixed, paraffin-embedded human Tonsil stained with CD43 Monoclonal Antibody (SPN/1094).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16150
Other Accession 6693, 632188
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPN/1094
Calculated MW 95, 115, or 135kDa
Additional Information
Gene ID 6693
Other Names Leukosialin, Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, CD43, SPN, CD43
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD43 (T-Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPN
Synonyms CD43
Function One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas
Research Areas
Citations (0)

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It recognizes a cell surface glycoprotein of 95/115/135kDa (depending upon the extent of glycosylation), identified as CD43. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.


Baeckstrom, D., et al. 1995. Expression of the leukocyte-associated sialo-glycoprotein CD43 by a colon carcinoma cell line. J. Biol. Chem. 270: 13688-13692. |

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$ 124.00
$ 324.00
$ 454.00
Cat# AH12363
(40 western blots)
Availability: 2-3 days
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