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CD53 (TSPAN25) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone 63-5A3 ]

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19397
Other Accession 963, 443057
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2b, kappa
Clone Names 63-5A3
Calculated MW 33-55kDa
Additional Information
Gene ID 963
Other Names Leukocyte surface antigen CD53, Cell surface glycoprotein CD53, Tetraspanin-25, Tspan-25, CD53, CD53, MOX44, TSPAN25
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD53 (TSPAN25) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD53
Synonyms MOX44, TSPAN25
Function Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).
Cellular Location Cell membrane. Cell junction. Membrane; Multi-pass membrane protein Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes
Tissue Location B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells
Research Areas
Citations (0)

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Recognizes a protein of 33-55kDa, identified as CD53 (Workshop V; Code CD53.1). CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst.


Knapp, W. et al., Leucocyte typing IV, p 534 and p 541. Oxford Univ. Press. 1989 | Schlossman SF et al. eds. Leukocyte Typing V, p556-559, Oxford University Press, Oxford, 1995. | Kishimoto T et al. eds. Leukocyte Typing VI, Garland Publishing, New York, 1997. | Olweus J et al. CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells. J Immunol 1993, 151(2):707-716. | Mannion BA et al. Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin  (CD49d/CD29). J Immunol 1996, 157(5):2039-2047. | Carmo AM et al. Association of the transmembrane 4-superfamily molecule CD53 with a tyrosine phosphatase activity. Eur J Immunol 1995, 25(7):2090-2095. | Mollinedo F et al. Recurrent infectious diseases in human CD53 deficiency. Clin Diagn Lab Immunol 1997, 4(2):229-231

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$ 124.00
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$ 454.00
Cat# AH12760
(40 western blots)
Availability: 2-3 days
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