PNL2 (Melanoma Associated Antigen) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone PNL2 ]
|Application ||IHC, IF|
|Reactivity||Human, Mouse, Drosophila|
|Isotype||Mouse / IgG1|
|Calculated MW||Multiple (160kDa, 100kDa and <10kDa)|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||PNL2 (Melanoma Associated Antigen) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
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Anti-PNL2 is a novel monoclonal antibody, which has recently been introduced as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. The antigen recognized by PNL2 is different from Melan A and gp100. Its epitope is not destroyed by digestion with neuraminidase i.e. its epitope id not glycosylated. Anti-PNL2 may be most useful because of its high sensitivity for metastatic melanoma (87%), as opposed to 76% for anti-HMB45 and 82% for anti-MART-1. Anti-PNL2 labels intra-epidermal nevi while the dermal component of compound nevi are largely non-reactive with anti-PNL2. Antibodies against PNL2, MART-1 (Melan A) and HMB45 stain most clear cell sarcoma cells and a few cells in angio-myolipomas and lymphangioleiomyomatosis. Anti-PNL2 is a useful antibody for the identification of melanomas and clear cell sarcomas. Differential diagnosis is aided by the results from a panel of antibodies, including antibodies against HMB45, MART-1, tyrosinase, and MiTF.
Rochaix, P et al. PNL2, a New Monoclonal Antibody Directed against a Fixative-Resistant Melanocyte Antigen. Mod Pathol 2003;16(5):481-490. | J. A. Ramos-Vara and M. A. Miller. Immunohistochemical Identification of Canine Melanocytic Neoplasms With Antibodies to Melanocytic Antigen PNL2 and Tyrosinase: Comparison With Melan A. Veterinary Pathology OnlineFirst, published on September 21, 2010 as doi:10.1177/0300985810382095
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