Cytokeratin, Multi (Epithelial Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone KRT/457 ]
|Application ||WB, IHC-P, IF, FC|
|Other Accession||3851 (CK4), 3852 (CK5), 3853 (CK6A), 3854 (CK6B), 286887 (CK6C), 3856 (CK8), 3858 (CK10), 3860 (CK13), 3875 (CK18) (Human), P04259 (CK6B), P13647 (CK5), P19013 (CK4), P48668 (CK6C)|
|Reactivity||Human, Mouse, Rat, Monkey, Pig, Goat, Cow, Guinea Pig|
|Isotype||Mouse / IgG1|
|Calculated MW||Multiple KDa|
|Other Names||Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Cytokeratin-6D, CK-6D, Keratin-6A, K6A, Type-II keratin Kb6, Hom s 5, KRT6A, K6A, KRT6D|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Cytokeratin, Multi (Epithelial Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.|
|Tissue Location||Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath|
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Provided below are standard protocols that you may find useful for product applications.
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, including 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 53kDa (CK13) and 45kDa (CK18). This is a broad-spectrum antibody, which has been reported to differentiate epithelial tumors from non-epithelial tumors. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
Bartek J et. al. J Pathol, 1991, 164(3):215-24. ,Kasper M. Histochemistry, 1991, 95(6):613-20
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