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MAFB antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • IHC - MAFB antibody - N-terminal region AI10098
    MAFB antibody - N-terminal region (AI10098) in Human kidney cells using Immunohistochemistry
    Human kidney
  • WB - MAFB antibody - N-terminal region AI10098
    MAFB antibody - N-terminal region (AI10098) in Human HepG2 cells using Western Blot
    WB Suggested Anti-MAFB Antibody Titration: 1.25μg/ml
    Positive Control: HepG2 cell lysate
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q9Y5Q3
Other Accession Q9Y5Q3, NP_005452, NM_005461
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Dog, Guinea Pig, Horse, Bovine, Yeast
Predicted Human, Mouse, Rat, Zebrafish, Chicken, Guinea Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 36 kDa
Additional Information
Gene ID 9935
Alias Symbol KRML, MGC43127
Other Names Transcription factor MafB, Maf-B, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B, MAFB, KRML
Target/Specificity MAFB is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells.The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns.
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-MAFB antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMAFB antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAFB
Synonyms KRML
Function Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage- specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Background

This is a rabbit polyclonal antibody against MAFB. It was validated on Western Blot and immunohistochemistry by Abgent. At Abgent we manufacture rabbit polyclonal antibodies on a large scale (200-1000 products/month) of high throughput manner. Our antibodies are peptide based and protein family oriented. We usually provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).

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$ 232.00
Cat# AI10098
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