|Other Accession||Q9NR21, NP_065100, NM_020367|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine|
|Predicted||Mouse, Rat, Rabbit, Pig, Chicken, Dog, Horse, Bovine|
|Calculated MW||39 kDa|
|Alias Symbol||C12orf6, DKFZp779H0122|
|Other Names||Poly [ADP-ribose] polymerase 11, PARP-11, ADP-ribosyltransferase diphtheria toxin-like 11, ARTD11, PARP11, C12orf6|
|Target/Specificity||PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PARP11 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PARP11 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity (PubMed:25673562).|
|Cellular Location||Nucleus, nuclear pore complex. Note=Colocalizes with NUP153 at nuclear pores.|
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